Brain Fog, Stress & Sleep Test | Advance Neurotransmitter + Hormone Test

Understand What May Be Affecting Your Mood, Stress, Sleep & Mental Clarity

Do you feel mentally exhausted, emotionally overwhelmed, anxious, constantly stressed, unable to focus, or struggling to get refreshing sleep — even when you are trying your best to look after yourself?

Many people live with brain fog, fatigue, mood swings, poor concentration, burnout, low motivation, restless sleep, or emotional ups and downs without understanding what may be happening inside their body. Often, these symptoms may be linked to imbalances in neurotransmitters, stress hormones, adrenal rhythm, and sleep-regulating pathways.

The Advanced Neurotransmitter & Hormone Test is a comprehensive at-home dried urine test designed to provide deeper insight into your brain chemistry, stress response, emotional wellbeing, sleep quality, energy production, focus, and nervous system balance.

Using advanced LCMS laboratory technology, this powerful 50-marker panel measures neurotransmitters, cortisol, cortisone, melatonin, norepinephrine, epinephrine, and additional neuroendocrine biomarkers to help identify possible biochemical imbalances linked to stress, anxiety, burnout, poor sleep, fatigue, brain fog, mood instability, and cognitive performance.

Why This Test Matters

Your mood, sleep, stress response, focus, and energy are not controlled by one single factor.

They are influenced by a complex relationship between:

• Brain chemistry
• Stress hormones
• Sleep rhythm
• Adrenal function
• Nervous system balance
• Neurotransmitter pathways

When these systems are out of balance, you may feel like something is wrong, even when routine tests look normal.

This test helps provide a clearer picture of what may be happening inside your body.

Who Is This Test For?

This test may be suitable if you experience:

• Stress or burnout
• Anxiety or low mood
• Poor sleep or insomnia
• Brain fog
• Fatigue or low energy
• Mood swings
• Poor concentration
• Low motivation
• Panic feelings
• PMS or PMDD symptoms
• ADHD-related symptoms
• Emotional overwhelm
• Difficulty relaxing
• Feeling “wired but tired”

This test is suitable for both adults and children when appropriate.

What Does This Test Measure?

Neurotransmitter Markers

This test measures key neurotransmitters and related metabolites, including:

• Tryptophan (Trp)
• Serotonin (5-HT)
• 5-Hydroxyindoleacetic Acid (5-HIAA)
• Gamma-Aminobutyric Acid (GABA)
• Glycine (Gly)
• Taurine (Tau)
• Glutamate (Glu)
• Glutamine (Gln)
• Histidine (His)
• Histamine (HIST)
• N-Methylhistamine (N-MeHist)
• Phenylethylamine (PEA)
• Tyrosine (Tyr)
• Tyramine (Tyra)
• Dopamine (DA)
• 3,4-Dihydroxyphenylacetic Acid (DOPAC)
• Homovanillic Acid (HVA)
• Normetanephrine (NMN)
• Vanillylmandelic Acid (VMA)
• Kynurenine (Kyn)
• Kynurenic Acid (KynAc)
• 3-Hydroxykynurenine (3OHKyn)
• Xanthurenic Acid (Xanth)

Stress, Adrenal & Sleep Rhythm Markers

This advanced profile also includes:

• Free Cortisol (FC) ×4
• Free Cortisone (FCn) ×4
• 6-Sulfatoxymelatonin (MT6s) ×4
• Norepinephrine (NE) ×5
• Epinephrine (Epi) ×5
• Creatinine (Crtn) ×5

These markers help assess daily stress patterns, adrenal rhythm, sleep-wake cycle, melatonin metabolism, and urine concentration for accurate interpretation.

Why Test Neurotransmitters, Cortisol and Melatonin Together?

Testing neurotransmitters alone gives useful information.

But combining neurotransmitters with cortisol, cortisone and melatonin gives a deeper view of how your body is managing stress, sleep and emotional balance.

This can help identify patterns linked to:

• Chronic stress
• Poor sleep rhythm
• Anxiety symptoms
• Low mood
• Fatigue
• Adrenal dysregulation
• Brain fog
• Emotional instability
• Reduced resilience

Cortisol and cortisone help assess stress response, while melatonin helps evaluate sleep-wake rhythm. Neurotransmitters provide insight into brain chemistry and nervous system balance.

Why Neurotransmitters Are Important

Neurotransmitters are chemical messengers that help your brain and nervous system communicate.

They influence:

• Mood
• Sleep
• Focus
• Motivation
• Memory
• Appetite
• Stress response
• Relaxation
• Emotional stability

For example:

• Serotonin is linked to calmness, mood and sleep
• Dopamine is linked to motivation, focus and reward
• GABA helps calm the nervous system
• Glutamate supports brain activity and learning
• Norepinephrine and Epinephrine are involved in the fight-or-flight stress response

Key Benefits

Understand Possible Root Causes

Instead of guessing why you feel tired, anxious, stressed or unable to sleep, this test gives measurable data about key biochemical pathways.

More Personalised Support

Results may help guide more targeted lifestyle, nutritional, stress-management or practitioner-led support.

Advanced Stress and Sleep Insight

The inclusion of cortisol, cortisone and melatonin markers helps assess how your body responds to stress and regulates sleep.

Easy Home Collection

No clinic visit is required. Samples are collected at home using dried urine strips throughout the day.

Specialist Report Included

Your report includes easy-to-read results, graphs, numbers and specialist laboratory comments.

How It Works

Step 1: Order Your Test Kit

Your test kit is delivered to your address in the UK.

Step 2: Collect Samples at Home

Collect dried urine samples using the provided strips at specific times during the day.

Step 3: Send Samples to the Laboratory

Use the included return envelope and shipping instructions. Customers are responsible for return shipping to the laboratory.

Step 4: Receive Your Results

Results are typically available within 3–5 working days after the laboratory receives your sample.

What Is Included in the Kit?

Your test kit includes:

• Test requisition form
• Symptom checklist
• Personal and medical history form
• Collection instructions
• Dried urine sample cards
• Instructions on how to use the collection kit
• Return envelope
• Shipping instructions

Important Information

• Free delivery in the UK
• Laboratory fee included
• No additional laboratory cost or tax
• Customers are responsible for return shipping
• Test must be used within 12 months of purchase
• Not suitable for individuals with compromised kidney function
• Follow collection instructions carefully
• Avoid alcohol, nicotine, bananas, pineapple and walnuts on the day of testing as instructed

Take Control of Your Mood, Stress and Sleep

If you feel stressed, anxious, exhausted, emotionally unbalanced or unable to sleep properly, this advanced test may help you understand what your body is trying to tell you.

The Advanced Neurotransmitter & Hormone Test II gives you detailed insight into brain chemistry, stress hormones, sleep rhythm and nervous system balance, helping you move from guessing to understanding.

Test Info

Test ID: U-343 | LCMS Neurotransmitters and Diurnal Hormones II Trp, 5-HT, 5-HIAA, GABA, Gly, Tau, Glu, Gln, His, HIST, N-MeHist, PEA, Tyr, Tyra, DA, DOPAC, HVA, NE(x5), NMN, Epi(x5), VMA, Kyn, KynAc, 3OHKyn, Xanth, Crtn(x5), FC(x4), FCn(x4), MT6s(x4)

Sample Type: Dried Urine

Technology: Advanced LCMS Analysis