Advanced Sleep Hormone, Cortisol, Melatonin, Norepinephrine & Epinephrine Assessment with 24 Biomarkers and Specialist Interpretation Included

Struggling with poor sleep, stress, fatigue, burnout, anxiety, frequent waking, or low energy? The Sleep Balance Profile + Diurnal Norepinephrine & Epinephrine Test (UDH II) is an advanced at-home hormone assessment designed to help identify possible hormonal and neuroendocrine imbalances affecting sleep quality, stress response, circadian rhythm, adrenal balance, and overall wellbeing.

Using advanced LCMS (Liquid Chromatography–Mass Spectrometry) laboratory analysis, this comprehensive sleep and stress profile measures melatonin metabolites, cortisol rhythm, cortisone levels, norepinephrine, and epinephrine across four collection times throughout the day to provide a clearer picture of the body’s natural sleep-wake cycle and stress response.

The test uses simple dried urine spot (DUS) collection from the comfort of your home with specialist laboratory interpretation included.

What Does This Test Measure?

This advanced sleep and stress profile evaluates hormones involved in:

• Sleep quality
• Circadian rhythm
• Stress response
• Adrenal balance
• Nervous system activity
• Recovery and resilience
• Wakefulness and arousal regulation

Biomarkers Included

Sleep Hormone

• Melatonin Metabolite 6-Sulfatoxymelatonin (MT6s ×4)

Stress & Adrenal Hormones

• Free Cortisol (FC ×4)
• Free Cortisone (FCn ×4)

Neuroendocrine Stress Markers

• Norepinephrine (NE ×4)
• Epinephrine (Epi ×4)

Additional Biomarker

• Creatinine (Crtn ×4)

Who May Benefit From This Test?

This advanced hormone profile may be suitable for individuals experiencing:

• Difficulty falling asleep
• Frequent waking during the night
• Early morning waking
• Poor sleep quality
• Chronic stress or burnout
• Anxiety or racing thoughts
• Daytime fatigue
• Low energy or poor recovery
• Brain fog or poor concentration
• Mood changes or irritability
• Stress-related sleep issues
• Shift work sleep disruption
• Adrenal stress symptoms
• Circadian rhythm imbalance
• Sleep and nervous system dysregulation

Why This Test Matters

Sleep problems are often connected to stress hormones, circadian rhythm imbalance, and nervous system dysregulation. Cortisol, melatonin, norepinephrine, and epinephrine all play important roles in regulating the body’s sleep-wake cycle, energy levels, recovery, and stress adaptation.

When these hormone patterns become disrupted, individuals may experience:

• Insomnia
• Frequent waking
• Fatigue
• Anxiety
• Poor recovery
• Burnout
• Mood changes
• Brain fog
• Low motivation
• Weight gain

This profile helps provide a more complete understanding of the interaction between stress hormones, adrenal function, circadian rhythm, and sleep quality.

Key Benefits of the Sleep Balance Profile

24-Hour Sleep-Wake Hormone Assessment

Measures hormones across four collection times to evaluate natural daily hormone rhythm and circadian balance.

Advanced Sleep & Stress Hormone Analysis

Evaluates melatonin, cortisol, cortisone, norepinephrine, and epinephrine using highly sensitive LCMS laboratory technology.

Stress Response Evaluation

Norepinephrine and epinephrine are key hormones involved in stress adaptation, wakefulness, nervous system activation, and adrenal response.

Circadian Rhythm Assessment

Provides insight into natural hormone fluctuations throughout the day and night to help evaluate circadian rhythm balance.

Convenient At-Home Collection

Simple dried urine spot collection from home with no large urine containers required.

Specialist Interpretation Included

Your report includes biomarker graphics, numerical results, and laboratory comments from a Hormone Specialist PhD Doctor.

Advanced LCMS Laboratory Technology

This test uses LCMS (Liquid Chromatography–Mass Spectrometry), considered one of the most advanced and accurate methods available for hormone analysis.

Benefits of LCMS include:

• High analytical sensitivity
• Improved specificity
• Accurate low-level hormone detection
• Extended linear range
• Advanced hormone and neuroendocrine profiling

Mass spectrometry is widely regarded as a gold-standard laboratory technology for complex hormone assessment.

Simple At-Home Testing

Collect your dried urine spot samples from home using the collection kit provided and return them to the laboratory for analysis.

The test kit includes:

• Test Requisition Form
• Symptom Checklist
• Collection Instructions
• Dried Urine Sample Cards
• Return Envelope
• Shipping Instructions

Results are typically available within 3–5 working days after the laboratory receives your samples.

The laboratory fee is included within the price of the test. No additional laboratory fees apply. Customers are responsible for shipping their samples to the laboratory.

Suitable For Individuals & Clinics

This advanced sleep and stress hormone profile is suitable for:

• Individuals seeking better sleep and recovery
• Functional medicine practitioners
• Wellness clinics
• Nutritional therapists
• Hormone practitioners
• Integrative health professionals
• Healthcare clinics monitoring stress and adrenal balance

Take Control of Your Sleep, Stress & Recovery

Many individuals remain unaware that hormone imbalance and stress dysregulation may be hidden contributors to insomnia, poor recovery, anxiety, burnout, and sleep disruption.

The Sleep Balance Profile + Diurnal Norepinephrine & Epinephrine Test helps provide a clearer understanding of your sleep hormones, stress response, circadian rhythm, and nervous system balance — supporting a more informed and personalised approach to improving sleep quality and overall wellbeing.