Neurotransmitter & Sleep Hormone Test

Advanced Brain Fog, Stress, Anxiety, Sleep & Mood Analysis | 42 Biomarkers

The Neurotransmitter & Sleep Hormone Test is an advanced at-home laboratory assessment designed to evaluate neurotransmitter balance, stress hormone function, cortisol rhythm, sleep hormone melatonin production, mood regulation, sleep quality, and neuroendocrine health.

This comprehensive profile combines advanced LCMS neurotransmitter testing with diurnal cortisol and melatonin analysis to provide deeper insight into how stress, hormones, and brain chemistry may affect your physical and emotional wellbeing.

The test includes 42 biomarkers and is suitable for both adults and children.

What Does This Test Measure?

This advanced profile analyses:

Neurotransmitters

Chemical messengers that influence:

• Mood
• Anxiety
• Motivation
• Focus
• Memory
• Sleep
• Cognitive performance
• Emotional wellbeing

Stress Hormones

Assessment of:

• Free Cortisol
• Free Cortisone
• Daily cortisol rhythm
• Stress response patterns

Sleep Hormones

Melatonin metabolite analysis to evaluate:

• Sleep-wake cycles
• Circadian rhythm function
• Sleep quality

42 Biomarkers Included

Neurotransmitter Markers

Includes advanced LCMS analysis of:

• Serotonin (5-HT)
• Dopamine (DA)
• GABA
• Norepinephrine
• Epinephrine
• Glutamate
• Histamine
• Glycine
• Taurine
• Tyrosine
• Kynurenine Pathway Markers
• Additional neurotransmitter metabolites

Diurnal Hormone Markers

• Free Cortisol ×4
• Free Cortisone ×4
• 6-Sulfatoxymelatonin (MT6s) ×4
• Creatinine ×5

Why Neurotransmitter Testing Matters

Neurotransmitters are essential chemical messengers used by the nervous system to communicate between nerve cells and regulate important body functions.

Neurotransmitter imbalances may influence:

• Anxiety
• Depression
• Brain fog
• Stress tolerance
• Sleep quality
• Fatigue
• ADHD-related symptoms
• Mood swings
• Focus and concentration
• Emotional wellbeing

This test helps identify possible biochemical imbalances that may contribute to ongoing symptoms and poor mental performance.

Symptoms This Test May Help Investigate

Mood & Mental Health

• Anxiety
• Depression
• Mood swings
• Panic attacks
• Irritability
• Emotional instability
• OCD-related symptoms

Cognitive & Brain Health

• Brain fog
• Poor concentration
• Forgetfulness
• ADHD-related symptoms
• Mental fatigue
• Memory difficulties

Stress & Adrenal Symptoms

• Burnout
• Chronic stress
• Fatigue
• Poor stress tolerance
• Nervousness
• Sleep disruption

Sleep & Energy

• Insomnia
• Difficulty staying asleep
• Non-restorative sleep
• Low motivation
• Daytime tiredness

Hormonal & Neuroendocrine Symptoms

• PMS
• PMDD
• Low libido
• Stress-related hormone imbalance

Key Features

• 42 total biomarkers
• Advanced LCMS laboratory analysis
• Diurnal cortisol & melatonin assessment
• Neurotransmitter pathway analysis
• At-home dried urine collection
• Non-invasive testing
• Suitable for adults and children
• Specialist PhD interpretation included
• Clinical literature-cited report
• UK delivery included
• Laboratory fee included
• Results available within 3–5 working days after laboratory receives samples

Why Assess Cortisol & Neurotransmitters Together?

Stress hormones and neurotransmitters constantly interact.

Chronic stress may alter:

• Cortisol rhythm
• Dopamine function
• Serotonin balance
• Sleep quality
• Energy production
• Emotional regulation

By testing neurotransmitters alongside cortisol and melatonin, this profile provides a more complete overview of neuroendocrine health and stress physiology.

Benefits of This Advanced Profile

Comprehensive Neuroendocrine Assessment

Provides insight into both neurotransmitter and stress hormone balance.

Objective Functional Data

Offers measurable biomarker information to complement clinical assessments.

Personalised Health Insights

Helps healthcare practitioners identify potential imbalances and guide targeted interventions.

Stress & Sleep Evaluation

Assesses cortisol rhythm and melatonin metabolism associated with:

• Sleep quality
• Burnout
• Fatigue
• Stress resilience

Mood & Cognitive Support

Supports investigation of symptoms related to:

• Anxiety
• Depression
• Focus
• Mood
• Cognitive function

How Sample Collection Works

The test uses convenient dried urine collection.

Four urine samples are collected throughout the day:

• Morning
• Mid-morning
• Early evening
• Bedtime

Samples are collected onto filter strips and dried before being returned to the laboratory.

This non-invasive collection method is simple, practical, and suitable for home use.

What’s Included in the Kit?

Your kit includes:

• Test requisition form
• Symptom checklist
• Collection instructions
• Dried urine collection cards
• Return envelope
• Shipping guidance

Results & Specialist Interpretation

Results are typically available within: 3–5 working days after the laboratory receives your samples.

Your confidential report includes:

• Easy-to-read graphics
• Biomarker values
• Specialist PhD interpretation
• Clinical comments
• Functional health insights

Suitable For

This test may be beneficial for individuals experiencing:

• Anxiety
• Depression
• Chronic stress
• Burnout
• Poor sleep
• Brain fog
• Mood instability
• ADHD-related symptoms
• Low energy
• Fatigue
• Cognitive difficulties
• Stress-related hormone imbalance

Frequently Asked Questions

Is this test suitable for home use?

Yes. The test is designed for easy at-home sample collection.

Is the test invasive?

No. This is a non-invasive dried urine test.

Is the laboratory fee included?

Yes. No additional laboratory fee or tax is required.

How quickly will I receive my results?

Results are generally available within 3–5 working days after the laboratory receives your samples.

Is this test suitable for children?

Yes. The test is suitable for both adults and children.

What technology is used?

Advanced LCMS (Liquid Chromatography–Mass Spectrometry) analysis.

Test Info

Test ID: U-342 | LCMS Neurotransmitters and Diurnal Hormones I Trp, 5-HT, 5-HIAA, GABA, Gly, Tau, Glu, Gln, His, HIST, N-MeHist, PEA, Tyr, Tyra, DA, DOPAC, HVA, NE, NMN, Epi, VMA, Kyn, KynAc, 3OHKyn, Xanth, Crtn(x5), FC(x4), FCn(x4), MT6s(x4)

Sample Type: Dried Urine

Technology: Advanced LCMS (Liquid Chromatography–Mass Spectrometry) analysis with specialist laboratory interpretation included in your personalised laboratory report.